Evidence of impaired cisapride metabolism in neonates

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منابع مشابه

Effects of cisapride on QTc interval in neonates.

AIM Prospective survey of the effects of cisapride on QTc interval in neonates given cisapride. METHODS QTc interval was determined just before and 2.9 (0.9) days after outset of the treatment in 49 neonates treated with cisapride between 1 August 1995 and 29 February 1996. RESULTS Cisapride significantly increased QTc interval (p = 0.0001), and this was higher when birthweight or gestation...

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Effects of cisapride on QTc interval in term neonates.

BACKGROUND Cisapride administration for 48 hours has been shown to increase heart rate corrected QT (QTc) interval in preterm neonates. Accumulation of the drug because of liver enzyme immaturity has been suggested to be the reason. If this is correct, a longer survey of QTc interval should disclose an increase even in term neonates. OBJECTIVE A prospective survey of the effects of cisapride ...

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Annotations The risks and benefits of cisapride in premature neonates, infants, and children

The Medicines Control Agency and the Committee on Safety of Medicines (CSM) recently stated that cisapride is contraindicated in infants born before 36 weeks’ gestation for three months after birth, and that there is insuYcient data to support the use of cisapride in children up to 12 years of age. These statements need qualification. Many believe cisapride to be a safe and useful agent in a va...

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The risks and benefits of cisapride in premature neonates, infants, and children.

The Medicines Control Agency and the Committee on Safety of Medicines (CSM) recently stated that cisapride is contraindicated in infants born before 36 weeks’ gestation for three months after birth, and that there is insuYcient data to support the use of cisapride in children up to 12 years of age. These statements need qualification. Many believe cisapride to be a safe and useful agent in a va...

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ژورنال

عنوان ژورنال: British Journal of Clinical Pharmacology

سال: 2001

ISSN: 0306-5251

DOI: 10.1046/j.0306-5251.2001.01470.x